hy 10423  (MedChemExpress)

Journal: Pharmaceutics

Article Title: High-Throughput/High Content Imaging Screen Identifies Novel Small Molecule Inhibitors and Immunoproteasomes as Therapeutic Targets for Chordoma

doi: 10.3390/pharmaceutics15041274

Figure Lengend Snippet: List of cherry-picked compounds. The top 50 compounds were selected as positive hits after the primary screen. Average Z-score and standard deviation between the two replicate plates were considered as criteria for selecting these potential hits. The table shows compounds with different mechanisms of action were qualified for cherry-picking, including the proteasomal inhibitors.

Article Snippet: OSI-027 , HY-10423 , −5.39 , 0.085 , OSI-027 is an ATP-competitive mTOR kinase activity inhibitor. OSI-027 targets both mTORC1 and mTORC2 , Medchem Express.

Techniques: Standard Deviation, Activity Assay, Expressing, Inhibition, Activation Assay, Histone Deacetylase Assay, Blocking Assay, Binding Assay, Modification, In Vitro